2 edition of Nucleic acid metabolism, cell differentiation, and cancer growth found in the catalog.
Nucleic acid metabolism, cell differentiation, and cancer growth
International Symposium for Cellular Chemistry, 2d, Otsu, Japan, 1966
|Contributions||Cowdry, Edmund Vincent, 1888-,, Senoo, Sachimaru, 1915-,|
|LC Classifications||QH607 I5 1966|
|The Physical Object|
|Number of Pages||483|
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Nucleic Acid Metabolism Cell Differentiation and Cancer Growth: Proceedings of the second international symposium for cellular chemistryCited by: 1. The cancer cell possesses an hereditary defect in the normal mechanism of control of cell division. Since the nucleic acids form a chemical basis of heredity in the cell it is reasonable to suspect an alteration in nucleic acids in the process of carcinogenesis.
This implies some sort of qualitative alteration in the information transfer by: 8. METABOLIC REPROGRAMMING AND ONCOMETABOLITES IN CANCER.
Altered metabolic activity supports anabolic growth during nutrient-replete conditions, catabolism to support cell survival during nutrient limitation, and fortification of redox homeostatic systems to counteract the metabolic effects of oncogene activation, tumor suppressor loss, and other stresses ().Cited by: Nucleic acid - Nucleic acid - Nucleic acid metabolism: Replication, repair, and recombination—the three main processes of DNA metabolism—are carried out by specialized machinery within the cell.
DNA must be replicated accurately in order to ensure the integrity of the genetic code. Errors that creep in during replication or because of damage after replication must be repaired. An alternative approach is to target acetate metabolism. Although a major function of the mitochondria is to provide acetyl-CoA to the cell, cancer cells can also use acetate to support cell growth and survival during metabolic stress (hypoxia or nutrient deprivation) (96, ).
The cytosolic enzyme acetyl-CoA synthase 2 (ACCS2), which converts Cited by: Nucleic acid metabolism is the process by which nucleic acids (DNA and RNA) are synthesized and c acids are polymers of tide synthesis is an anabolic mechanism generally involving the chemical reaction of phosphate, pentose sugar, and a nitrogenous ction of nucleic acid is a catabolic reaction.
Additionally, parts of the nucleotides or. The final chapter deals with two special areas of plant biology where the expression of the nucleic acids is seen in striking relief, the formation of plant tumors, and the growth and expression of plant viruses.
This book is a valuable resource for plant biochemists, molecular biologists, senior graduate students, and research workers. Nucleic Acid Metabolism Cell Differentiation and Cancer Growth: Proceedings of the second international symposium for cellular chemistry.
By J. Chayen. Topics: Book Review. Year: OAI identifier: oai: Provided by: PubMed Author: J. Chayen. Start studying Nucleic Acid Metabolism. Learn vocabulary, terms, and more with flashcards, games, and other study tools. used in the treatment of hairy cell leukemia and chronic lymphocytic leukemia and lymphomas.
This drug is used to treat CANCER PATIENTS with high levels of. Nucleic acids are present in most of the foods you eat. During digestion, nucleic acids including DNA and various RNAs are broken down into their constituent nucleotides. These nucleotides are readily absorbed and transported throughout the body to be used by individual cells during nucleic acid metabolism.
Anabolic Reactions. Nucleic acid-based aptamers are emerging as therapeutic antagonists of disease-associated proteins such as receptor tyrosine kinases. They are selected by an in vitro combinatorial chemistry approach, named Systematic Evolution of Ligands by Exponential enrichment (SELEX), and thanks to their small size and unique chemical characteristics, they possess several advantages over antibodies as Cited by: Lipid Metabolism R G Langdon, and and A H Phillips Annual Review of Biochemistry Nucleic Acids, Purines, Pyrimidines (Nucleotide Synthesis) S C Hartman, and and J M Buchanan Annual Review of Biochemistry Metabolism of Nucleic Acids E S CanellakisCited by: The progression of cancer is associated with increases in amino acid uptake by cancer cells.
Upon their entry into cells through specific transporters, exogenous amino acids are used to synthesize proteins, nucleic acids and lipids and to generate ATP. The essential amino acid leucine is also important for maintaining cancer-associated signaling by: 8.
- Monomeric units of nucleic acids (DNA and RNA) - Energy metabolism (ATP) - Components of coenzymes (NAD+) - Activated intermediates (UDP-sugars: significant with diabetes) - important for transport of sugars - Signaling and regulatory molecules (cAMP) - secondary messengers - adenosine - control of coronary blood flow.
The efficient delivery of foreign nucleic acids (transfection) into cells is a critical tool for fundamental biomedical research and a pillar of several biotechnology industries. There are currently three main strategies for transfection including reagent, instrument, and viral based methods.
Each technology has significantly advanced cell transfection; however, reagent based methods have Cited by: 7. Incell-free nucleic acids (cfNAs) were observed in the human blood circulation for the first time .InLeon and colleagues  reported that cell-free DNA (cfDNA) was present at concentrations ranging between 0 and 2 μg/mL in the serum of patients with breast cancer and that it was possible to analyze variations in the amount, depending on the stage of the disease and the Cited by: The experiments of Griffith, inwere one of the first steps toward proof that nucleic acids are the genetic material.
He used different strains of the bacterium pneumococcus to demonstrate a genetic ‘transformation’ of one strain type into another.
Different strains of pneumococcus can be distinguished by the type of polysaccharide found in the cell capsule. Abstract. Nucleic acids are polymers of nucleotides. The latter are composed of a five-carbon sugar (d-ribose or d-deoxyribose) linked both to a nitrogen base (purine or pyrimidine) and a phosphate group (nucleosides are nucleotides without this phosphate group).The purine and pyrimidine nucleotides which occur most frequently in the nucleic acids of cells are illustrated in figure Cited by: 4.
1α,25(OH) 2 D 3 (vitamin D 3) is crucial for mineral homeostasis in mammals, but the precise effects of 1α,25(OH) 2 D 3 in adipose tissue remain to be clarified in vivo. The initial hydroxylation is catalyzed by liver microsomal cytochrome P 2R1 (CYP2R1), which is conserved in vertebrates.
To probe the physiological function(s) of 1α,25(OH) 2 D 3 in teleosts, we generated two Cited by: In another study, Sun et al.  indicated that crocin inhibits proliferation and nucleic acid synthesis and induces apoptosis in the human tongue squamous cell carcinoma cell line Tca In.
Cancer Cell Metabolism. Research in cancer cell metabolism focuses on altered cellular metabolism that supports the cancer phenotype characterized by unchecked cellular proliferation, resistance to metabolic and oxidative stress, ability to evade programmed cell death, reduced dependence on growth factor signals, insensitivity to growth inhibitory signals, and resistance to therapeutic.
The PI3K 33 pathway thus plays a dual role in the cancer metabolism, by providing growth, survival and proliferation signals to the cancer cell, but also influencing the cells metabolism, thus.
A nucleotide is composed of three distinctive chemical sub-units: a five-carbon sugar molecule, a nitrogenous base—which two together are called a nucleoside—and one phosphate all three joined, a nucleotide is also termed a "nucleoside monophosphate", "nucleoside diphosphate" or "nucleoside triphosphate", depending on how many phosphates make up the phosphate group.
Introduction. The investigation of embryonic stem cell (ESC) 6 maintenance and differentiation in tissue culture has revealed a wealth of information about the earliest steps of development. There are some differences in chromatin architecture and dynamics between ESCs in culture and those in the preimplantation embryo ().However, in contrast to in vivo tissue, cultured cells Cited by: Nucleotide Metabolism • de novo Pyrimidine Biosynthesis Summary Pyrimidine Ring Synthesis Occurs First and Then it is Attached to Ribose ATCase is a Major Regulator and Balance of Pyrimidine/Purine Nucleotides ATP Activates, Favors Pyrimidines.
CTP Inhibits. Laktionov, P. et al. Cell-surface-bound nucleic acids: free and cell-surface-bound nucleic acids in blood of healthy donors and breast cancer patients.
Ann. Y Acad. Sci.– The term ‘lipids’ refers to a class of biological molecules primarily composed of hydrocarbons such as fatty acids, glycerolipids, sphingolipids and sterol lipids. Lipids take part in a variety of physiological functions and have specific roles depending on their chemical structure and localisation within or outside cells.
For example, glycerolipids (e.g. triglycerides) are often used as Author: Jin Yan Lim, Hiu Yee Kwan. Benjamin S. Frank, author of Nucleic Acid Therapy in Aging and Degenerative Disease, has found that deteriorating cells can be rejuvenated if provided with substances that directly nourish them – substances such as nucleic acids.
DNA [deoxyribonucleic Author: Benjamin S Frank. Our assays are performed in a convenient well plate format. Quantitation is performed on either a colorimetric or fluorescence-based microplate reader.
Elucidating the roles that protein–nucleic acid complexes play in the regulation of transcription, translation, DNA replication, repair and recombination, RNA processing and translocation continues to revolutionize our understanding of cell biology, normal cell development and the mechanisms of disease.
the role of nucleotides in overall nucleic acid metabolism, the treatment is included in molecular biology. Both aspects will be considered here with the major emphasis directed toward relating defects in nucleotide turnover to either metabolic diseases or chemotherapy.
Nomenclature (pages 11 and 12). Overall metabolic pathways (page 4).File Size: KB. Abstract. The mechanisms by which genetic information is transmitted during reproduction and cell division and by which nucleic acids are replicated and nucleic acids and proteins are synthesized and degraded and by which these processes are controlled are so complex chemically that there are, consequently, many sites at which foreign compounds including drugs may have a direct effect on the Cited by: In many respects, the most remarkable chemical substances within the genome of eukaryotic cells are remarkable proteins which are the critical structural and functional units of living cells.
The specifications for everything that goes in the cell are natural digital-to-digital decoding process in an archive sequence by deoxyribonucleic acid (DNA) and an articulate construction by ribonucleic Cited by: 1. Cancer cells exhibit a dynamic metabolic landscape and require a sufficient supply of nucleotides and other macromolecules to grow and proliferate.
To meet the metabolic requirements for cell growth, cancer cells must stimulate de novo nucleotide synthesis to obtain adequate nucleotide pools to support nucleic acid and protein synthesis along with energy preservation, signaling activity Cited by: Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers.
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. In this paper, we describe the metabolic changes as well as the mechanisms of resistance to Cited by: Metabolic reprogramming is a staple of cancer cell growth and proliferation.
Both essential and nonessential amino acids (EAAs and NEAAs) support altered metabolism by Cited by: 1. Nucleic acids are present in most of the foods you eat. During digestion, nucleic acids including DNA and various RNAs are broken down into their constituent nucleotides.
These nucleotides are readily absorbed and transported throughout the body to be used by individual cells during nucleic acid : J.
Gordon Betts, Kelly A. Young, James A. Wise, Eddie Johnson, Brandon Poe, Dean H. Kruse, Oksana Ko. ADVERTISEMENTS: The metabolism of carbohydrates, lipids, nucleic acids and proteins, but we have already underlined the fact that this division is rather arbitrary; it is justified mainly because it facilitates the presentation.
In fact — as observed repeatedly — inter-relations between various types of compounds are numerous and the entire cellular metabolism must be regarded [ ]. Signaling in Control of Cell Growth and Metabolism.
Patrick S. Ward 1, 2 and factor and mTOR kinase regulate the uptake and utilization of amino acids for protein and nucleic acid synthesis, as well as for the supply of intermediates to the mitochondrial Krebs cycle.
and impair hematopoietic differentiation. Cancer Cell. IDH1 and 2, metabolic enzymes that catalyze the conversion of isocitrate into a-KG, play key roles in energy production and are mutated in a variety of cancer cell types. In addition, mutant forms of IDH1 and 2 catalyze the formation of 2HG and drive cancer growth by blocking cellular differentiation and inducing cellular proliferation.Langbein, S.
et al. Expression of Transketolase TKTL1 Predicts Colon and Urothelial Cancer Patient Survival: Warburg Effect Reinterpreted. Br. J. Cancer. 94, (). Mannava, S. et al.
Direct Role of Nucleotide Metabolism in C-Myc-Dependent Proliferation of .Phases of cell cycle: G0, G1, S, G2, M; Growth arrest. Apoptosis (Programmed Cell Death) Specialized Eukaryotic Cells and Tissues.
Nerve Cell/Neural. Cell body (site of nucleus and organelles) Axon (structure, function) Dendrites (structure, function) Myelin sheath, Schwann cells, oligodendrocytes, insulation of axon.